The Academy of Sciences of the Dominican Republic was founded on December 20, 1974, and it was recognized and incorporated by a Presidential Decree on June 1975. The Senate Chamber of the Dominican Republic designated the Academy as advisor of the legislative.

The Academy has also signed standing agreements with several universities, and its opinion is requested in legal courts in matters related to the environment and other areas in which an independent expert opinion would be necessary. Since the year 2000 the Academy is also a member of the National Council for Science and Technology.